Transgenics as Edible Vaccines for Hepatitis B, Serum, Safety Concerns, Transgenic tobacco, Surface Antigen, Banana, Mice

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Home >> Plant Biotechnology and Genomics >>Molecular Farming Pharming >>Transgenics as Edible Vaccines for Hepatitis B

Transgenic as edible vaccines for hepatitis B
An important target for vaccines is hepatitis B, a virus causing a chronic liver disease. Serum derived antigens were initially used for immunization against this disease, but due to a variety of safety concerns against this vaccine, recombinant vaccines were developed in yeast. These recombinant vaccines also failed due to high expense and lack of facilities at several places for their production. Therefore, in 1990s and in the year 2000, transgenic tobacco and potato were produced, which expressed hepatitis B surface antigen (HbsAg).

In the year 2002 transgenic carrot plants were also produced at Giessen University in Germany which have the potenital as an editle vaccine against hepatitis B. In future, HbsAg may also be produced in banana, which can be eaten raw. Thus, it is hoped that the transgenic plants, without any treatment of edible parts that are ingested, will provide for edible vaccines against hepatitis B for developing countries. It has already been shown that transgenic potato expressing HbsAg, when orally administered to mice, can elicit humoral immune responses.

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Factors Affecting Choice of Transgenic Plants for Vaccines Transgenic Tobacco, Potato and Banana as Edible Vaccines Transgenics as Edible Vaccines for Hepatitis B The Production of Vaccines in Transgenic Plants Alternative to Transgenic Plant for Vaccine Production Transgenic Plants for Antibodies Production of Antibodies in Transgenic Plants Transgenic Plants as Factories for Biopharmaceuticals Production of Biopharmaceuticals in Transgenic Plants Production of Glucocerebrosidase for 'Gaucher's Disease' Production of Hirudin (an Anticoagulant) for 'Thrombosis'