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  Home >> Molecular Biology Dictionary >> Map distance - Material Inheritance


Map distance

The standard measure of distance between loci, expressed in centiMorgans (cM). Estimated from recombination fraction via a mapping function (q.v.). For small recombination fractions, map distance equals the percentage of recombination (recombination frequency) between two genes. 1% recombination = 1 cM. Sometimes called a map unit. mapping Determining the location of a locus (gene or genetic marker) on a chromosome. See continuous map; linkage map; physical map.

Mapping function
A mathematical expression relating observed recombination fraction (q.v.) to map distance expressed in centiMorgans.

Two common mapping functions are those developed by Haldane (1919; J. Genet. 8: 299-309) and Kosambi (1944; Ann. Eugen., 12: 172-175). In both functions, the relationship between recombination fraction and map distance is approximately linear for recombination fractions less than 10%; as recombination fraction increases above 10% (up to its maximum of 50%), map distance is increasingly greater than recombination fraction.

MAS
See marker-assisted selection.

Mass selection
As practiced in plant and animal breeding, the choosing of individuals for reproduction from the entire population on the basis of individual phenotypes.

Map unit
See map distance; crossing-over unit.

Marker
An identifiable DNA sequence that facilitates the study of inheritance of a trait or a gene. Such markers are used in mapping the order of genes along chromosomes and in following the inheritance of particular genes: genes closely linked to the marker will generally be inherited with it. Markers must be readily identifiable in the phenotype, for instance by controlling an easily observable feature (such as eye colour) or by being readily detectable by molecular means, e.g., microsatellite markers (q.v.). See gene tracking.

Marker-assisted introgression
The use of DNA markers to increase the speed and efficiency of introgression (q.v.) of new gene or genes into a population. The markers will be closely linked to the gene(s) in question. marker-assisted selection (MAS) The use of DNA markers to increase the response to selection in a population. The markers will be closely linked to one or more quantitative trait loci (q.v.).

Marker gene
A gene of known function and known location on the chromosome. cf genetic marker.

Maternal effect
An effect attributable to some aspect of performance of the mother of the individual being evaluated.

Maternal inheritance
Inheritance controlled by extrachromosomal (cytoplasmic) factors that are transmitted through the egg.
matric potential A water potential component, always of negative value, resulting from capillary, imbibitional and adsorptive forces. See pressure potential.

 

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