students Logo
Home | Sitemap | Contact us | Search | Language
Left Right
  Home >> Molecular Biology Dictionary >>Human leukocyte - Antigen System homology

HLA
Human leukocyte antigen system. See major histocompatibility antigens.

HnRNA
Heterogeneous nuclear RNA; refers collectively to the variety of RNAs found in the nucleus, primary transcripts, partially processed RNAs and snRNA. The term hnRNA is often used just for the unprocessed primary transcripts, however.

Homologous
From the same source, or having the same evolutionary function or structure.

Homologous chromosomes
Chromosomes that occur in pairs and are generally similar in size and shape: one comes from the male parent and the other from the female. Such chromosomes contain the same linear array of genes.

Holoenzyme
see apoenzyme.

Holometabolous
An insect that undergoes complete metamorphosis to the adult from a morphologically distinct larval stage.

Homeobox
A DNA sequence found in several that are involved in the specification of organs in different body parts in animals; they are characteristic of genes that influence segmentation in animals. The homeobox corresponds to an amino acid sequence in the polypeptide encoded by these genes; this sequence is called the homeodomain.

Homeodomain
See homeobox

Homeotic mutation
A mutation that causes a body part to develop in an inappropriate position in an organism, such as the mutation in Drosophila that causes legs to develop on the head in place of antennae.

Homoalleles
Mutations that are both functionally and structurally allelic; mutations at the same site in the same gene.

Homologous recombination
The exchange of DNA fragments between two DNA molecules or chromatids of paired chromosomes (during crossing over) at the site of identical nucleotide sequences.

Homodimer
A protein with two identical polypeptide chains.

Homogametic sex
Producing similar gametes with regard to the sex chromosomes. In mammals, the XY male is hetrogametic, and the XX female is homogametic. See hetreogametic sex.

Homogenotization
A genetic technique used to replace one copy of a gene, or other DNA sequence within a genome, with an altered copy of that sequence.

The DNA is first cloned an then altered in some way, e.g., a transposon is inserted into a gene. The mutated gene copy can be used to replace the original gene by recombination in vivo. The incorporation of the mutated gene is usually selected, for example, by virtue of its containing a transposon encoded antibiotic resistance. See replacement.

Homokaryon
Cell with two or more identical nuclei as a result of fusion. Opposite: heterokaryon.

Homology
The degree of identity between individuals, or characters. The degree of identity the sequences of two nucleic acid molecules or the amino acid sequences of two protein molecules. Although sequence determination is the ultimate test of homology, useful estimates can be provided by either DNA-DNA or DNA-RNA hybridization.

Left Right