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  Home >> Molecular Biology Dictionary >> Genetic Complementation - Genetic Immunization

Genetic complementation
When two DNA molecules that are in the same cell together produce a function that neither DNA molecule can supply on its own. a.k.a. complementation.

Genetic drift
Change in allele frequency from one generation to another within a population, due to the sampling of finite numbers of genes that is inevitable in all real (finite) populations. The smaller the population, the greater is the genetic drift. Sooner or later (depending on the size of the population), genetic drift results in loss of alleles from a population, and hence leads to a loss of genetic variation. Because of this, the minimization of genetic drift is an important consideration for conservation of genetic resources. See genetic diversity.

Genetic engineering
Changes in the genetic constitution of cells (apart from selective breeding) resulting from the introduction or elimination of specific genes through modem molecular biology techniques.

This technology is based on the use of a vector for transferring useful genetic information from a donor organism into a cell or organism that does not possess it. See gene cloning. A broader definition of genetic engineering also includes selective breeding and other means of artificial selection.

Genetic disease
A disease that has its origin in changes to the genetic material. Usually refers to diseases that are inherited in a Mendelian fashion, although non-inherited forms may also result from DNA mutation.

Genetic distance
In AnGR: A measure of the genetic similarity between any pair of populations. Such distance may be based on phenotypic traits, allele frequencies or DNA sequences. For example, genetic distance between two populations having the same allele frequencies at a particular locus, and based solely on that locus, is zero. The distance for one locus is maximum when the two populations are fixed for different alleles. When allele frequencies are estimated for many loci, the genetic distance is obtained by averaging over these loci. (Source: FAO, 1999)

Genetic equilibrium
Condition in a group of interbreeding organisms in which the allele frequencies remain constant over time.

Genetic fingerprinting
A technique in which an individual's DNA is analysed to reveal the pattern of repetition of particular nucleotide sequences throughout the genome. See DNA fingerprint.

Genetic heterogeneity.
The situation in which different mutant genes produce the same phenotype.

Genetic immunization
Delivery to a host organism of a cloned gene that encodes an antigen. After the cloned gene is expressed, it elicits an antibody response that protects the organism from infection by a virus, bacterium or other disease causing organism

Genetic distancing
In AnGR: The collection of the data on phenotypic traits, marker allele frequencies or DNA sequences for two or more populations, and estimation of the genetic distances between each pair of populations: From these distances, the best representation of the relationships among all the populations may be obtained.

Genetic diversity
The heritable variation within and among populations which is created, enhanced or maintained by evolutionary forces. See biodiversity; mutation; genetic drift; gene re shuffling processes.

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