Cosmid
1. A plasmid vector which contains the two cos (cohesive) ends of phage lambda (Lamda) and one or more selectable markers such as an antibiotic resistance gene. Cosmids exploit certain properties of phage lambda (Lamda) to enable large, 40-50 kb, DNA fragments to be cloned at high efficiency. Cosmids and cosmid recombinants replicate as plasmids.
2. A type of vector used for cloning 35-45 kb of DNA. These are plasmids carrying a phage Lamda cos site (which allows packaging into Lamda capsids), an origin of replication and an antibiotic resistance gene. A plasmid of 40 kb is very difficult to put into bacteria, but can replicate once there. Cosmids, however, have a cos site, and thus can be packaged into (Lamda) allow efficient introduction into bacteria (you’ll have to look up the cos site elsewhere).