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  Home >> Molecular Biology Dictionary >> Bio-Informatics, Bio-synthesis

Bio-informatics
1. The use and organization of information of biological interest. In particular, it is concerned with organizing bio-molecular databases, in getting ,useful information out of such databases, in utilizing powerful computers for analysing such information, and in integrating information from disparate biological sources.
2. The discipline of obtaining information about genomic or protein sequence data. This may involve similarity searches of databases, comparing your unidentified sequence to the sequences in a database, or making predictions about the sequence based on current knowledge of similar sequences. Databases are frequently made publically available through the Internet, or locally at your institution

Biolistics (from biological + ballistics)
A technique to insert DNA into cells. The DNA is mixed with small metal particles - usually tungsten or gold - a fraction of a micrometre across. These are then fired into a cell at very high speed. They puncture the cell and carry the DNA into the cell. Biolistics has an advantage over transfection, transduction, etc., because it can apply to any cell, or indeed to parts of a cell. Thus use of biolistics has inserted DNA into animal, plant and fungal cells, and into mitochondria inside cells. a.k.a. microprojectile bombardment

Biological ageing
See senescence.

Biological control

See biocontrol.

Biological containmen

Restricting the movement of (genetically engineered) organisms by arranging barriers to prevent them from growing outside the laboratory. Biological containment can take two forms: making the organism unable to survive in the outside environment, or making the outside environment inhospitable to the organism. The latter is rarely suitable for bacteria, which, in principle, could survive almost anywhere.

Thus for bacteria and yeasts, the favoured approach is to mutate the genes in the organism so that they require a supply of a specific nutrient that is usually available only in the laboratory. If they get out, they then cannot grow. Making the environment unfriendly to the organisms is partly a biological control, partly a physical one. Thus, some of the first genetically engineered rice strains were develops in England (which is too cold for rice to grow) and tried in the field in Arizona (where it is too dry). Biological containment may also involve the use of vector molecules and host organisms which have been genetically disabled such that they can survive only in the peculiar conditions provided by the experiment and which are unavailable outside the laboratory

Biological diversity
See biodiversity (Source: FAO, 1999)

Biome

A major ecological community or complex of communities, extending over a large geographical area and characterized by a dominant type of vegetation.

Biometrics

See biometry.

Biometry
The application of statistical methods to the analysis of biological problems.

Biosphere

The part of the earth an d its atmosphere that is inhabited by living organisms.

Biosynthesis

1. Synthesis of compounds by living cells, which is the essential feature of anabolism.
2. Catabolism, the production of new cellular materials from other organic or inorganic chemicals

 

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