Typhoid Fever
Typhoid (Gr. typhodes = smoke) fever is contaminated food or water (contaminated by feces of infected humans or animals) borne disease caused by Salmonella typhi.

The organisms gain entry into the body through contaminated water supplies and the food material contaminated by the bacilli. A very low dose of S. typhi establishes the infection. The bacteria enter the lymphatic system in the Peyer’s patch of the intestine forming ulcer, and disseminated through the circulatory system. It invades the mononuclear phagocyte system and continues to multiple within the phagocytic blood cells. The organism grow and causes damage to the liver and gallbladder and sometimes to kidneys, spleen and lungs.