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Home >> Microbiology >> MIcrobial Diseases and Their Control >> Syphilis

Syphilis
Syphilis (Gr. syn = together; philein = to love) is a contagious sexually transmitted disease caused by a spirochete, namely, Treponema pallidum which is about 10-5 m in length and about 0.15m in diameter.

The pathogen enters the body through mucous membranes or minor breaks or abrasions of the skin. Once in the body, it migrates to the regional lymph nodes and rapidly spreads throughout the body. Syphilis occurs in three distinct stages. In primary stage, the pathogen multiples developing a characteristic lesion called chancre formed within 3-6 weeks. The secondary stage begins 6 to 8 weeks after appearance of the lesion. During this stage these is appearance of cutaneous lesions involving mucus membrane such as on lips, tongue, throat, penis, angina and other body surfaces. In addition, patient suffers from headache, low-grade fever, and enlargement of lymph nodes.

The tertiary stage occurs several years after the primary stage. Although, this stage is asymptomatic but can cause damage of any organ of the body especially damage to aorta resulting into death of patient or paralysis or may cause change in personality. The syphilis infected pregnant woman gives birth to still bady who is mentally retarded and neurologically impaired.

Pencillin is highly effective in syphilis treatment and the primary and secondary stages can be controlled by a single injection of benzathine penicillin G. In tertiary stage of syphilis, penicillin treatment must extend for longer period of time. Besides, public education and sexual hygiene are quite necessary.

 

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