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Home >> Industrial and Microbial Biotechnology >>Drug Discovery and Drug Designing >> Recombinant Proteins and Monoclonal Antibodies as Drugs

Recombinant Proteins and Monoclonal Antibodies as Drugs

Molecular biology exerted a profound influence on drug discovery, through the use of genetic information translated in the language of biochemistry and chemistry. One of the major uses of molecular biology in drug development is cloning and expressing genes that encode therapeutically useful proteins. The total number of such 'biotech' drugs, including recombinant proteins and monoclonal antibodies were, however, only -60 in the year 2000. In the year 1998 alone, out of 57 drugs that were introduced worldwide, 15 (26.3%) were either recombinant proteins or monoclonal antibodies. Besides recombinant insulin and interferons, several other recombinant proteins that are or will be used as drugs include the following: tissue plasminogen activator (tPA), erythro-poietin, granulocute-macrophage colony-stimulating factor, Herceptin, rituximat, etc

 

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