History of Drug Discovery Enzymes Receptors as Drug Targets, Molecules, Biochemistry, Cell Biology, Molecular Drug Target

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Drug Discovery and Drug Designing Drug Discovery and Drug Designing Introduction Early History of Drug Discovery History of Drug Discovery Enzymes/Receptors as Drug Targets Receptors as Drug Targets Enzymes as Drug Targets Molecular Biology for Drug Discovery Recombinant Proteins and Monoclonal Antibodies as Drugs Molecular basis of Disease Processes Target Identification and Validation Combinatorial Chemistry and HTS Organic Synthesis (Combinatorial Chemistry for Drug Discovery) Target-Oriented Organic Synthesis and Retrosynthetic Analysis

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Recent History of Drug Discovery: Enzymes/Receptors as Drug Targets

Developments in biochemistry also facilitated drug discovery, since many enzymes and receptor molecules discovered through the tools of biochemistry and cell biology later proved to be good drug targets. It ahs been shown that out of more than 500 molecular drug targets that are known, 45% are receptors and 28% are enzymes. The discovery and subsequent use of receptors and enzymes as drug targets will be discussed separately for receptors and enzymes

Relative Proportion of the Different Classes of Molecular Targets of Drug Therapy

1.	Receptors (45%)	2.	Enzymes (28%)`
3.	Hormones and growth factors (11%)	4.	DNA (2%)
5.	Nuclear receptors (2%)	6.	Ion channels (5%)
7.	Unknown (7%)

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Diversity-Oriented Organic Synthesis and Evolving Synthetic Analysis Solid Phase Synthesis for Drug Discovery Combinatorial Biocatalysis for Drug Disovery Synthesis of Bergenin Derivatives Drug Discovery in Cancer Research Microbial Genomics for New Antibiotics Genomics Drugs (Pharmacogenomics) Immunotoxins as Drugs Drug Designing Drug Designing by Blocking Enzyme Activity Drug Designing through Blocking Hormone Receptors Drug Designing through Inhibition of Nucleic Acid Synthesis Drug Designing Against Heterogeneous Targets