Drug Designing, Atomic Resolution, Pharmacological, Toxicological Properties, Three Dimensional Construction

Scholarships Dictionary Visa Details Study Abroad Exam Results Online Test Jobs

	Home
Drug Discovery and Drug Designing Drug Discovery and Drug Designing Introduction Early History of Drug Discovery History of Drug Discovery Enzymes/Receptors as Drug Targets Receptors as Drug Targets Enzymes as Drug Targets Molecular Biology for Drug Discovery Recombinant Proteins and Monoclonal Antibodies as Drugs Molecular basis of Disease Processes Target Identification and Validation Combinatorial Chemistry and HTS Organic Synthesis (Combinatorial Chemistry for Drug Discovery) Target-Oriented Organic Synthesis and Retrosynthetic Analysis

Home >> Industrial and Microbial Biotechnology >>Drug Discovery and Drug Designing >> Drug Designing

Your Ad Here	Drug Designing Drug designing is another area of biotechnology research which is being actively pursued. Several approaches are being used for this purpose and some of them will be briefly described in this section to give an elementary idea about this important and fascinating area of research. However, all these approaches are based on an exercise where we first acquire knowledge about active site that needs to be attacked by the drug and then utilize this information to design a drug that will not only bind to the chosen site but will also possess all other properties required of a drug. Therefore, drug designing will involve atleast three steps:
(i) Knowledge will have to be acquired about the site structure, upto the level of atomic resolutions, so that the accessible surface, which needs to be attacked, is known. (ii) A ligand will have to be designed that will fit the binding site; for this purpose the steric outline of the ligand should be complementary to the site and, therefore, these complementary features will have to be built in the ligand at appropriate positions. This should result in the maximum interactions between atoms of the ligand and the site, and is mainly achieved with the help of computer-aided methods. (iii) Once the ligand is designed to fit the binding site, ligand needs to be modified to have pharmacological and toxicological properties, while maintaining its affinity for the binding site. This and the above step (ii) will require three dimensional construction. Computers have provided methods which will allow automated site-directed drug designing.
Earlier in this chapter, while discussing the recent history of drug discovery, we emphasized that enzymes and receptors were discovered as the suitable targets of many drugs. These drugs may be discovered through the high throughput screening (HTS) of a combinatorial library that is prepared for this purpose. Combinatorial biocatalysis can also be used for drug discovery keeping in view the above two targets. However, the drugs may also be rationally designed keeping these targets in mind. Four approaches for rational designing of drugs, keeping appropriate targets (enzymes/receptors) in mind, will be briefly described in this section using suitable examples.	Your Ad Here

	Home
Diversity-Oriented Organic Synthesis and Evolving Synthetic Analysis Solid Phase Synthesis for Drug Discovery Combinatorial Biocatalysis for Drug Disovery Synthesis of Bergenin Derivatives Drug Discovery in Cancer Research Microbial Genomics for New Antibiotics Genomics Drugs (Pharmacogenomics) Immunotoxins as Drugs Drug Designing Drug Designing by Blocking Enzyme Activity Drug Designing through Blocking Hormone Receptors Drug Designing through Inhibition of Nucleic Acid Synthesis Drug Designing Against Heterogeneous Targets

Language >> English | Français | Español | Deutsch | Italiano | Portugues | Japanese | Korean | Sim-Chinese