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Genetic Code

Genetic code is defined as the sequence of nitrogen bases(nucleotides) in mRNA molecule which contains the information for the synthesis of protein molecules.

A codon is defined as the sequence of nitrogen bases (nucleotides) in mRNA which codes for a single amino acid.

Nirenberg and Mathaei (1961) experimentally proved that a single amino acid is determined by a sequence of there nitrogen bases. The sequence of three nitrogen bases determining a single amino acid is called a triplet code.

The genetic code has the following characteristics:
1. Triplet

A single amino acid is specified by a sequence of three nucleotides in the mRNA. This is called a codon. Hence, a codon is a triplet as it is formed of three bases

mRNA with codons.

Genetic Code

2. Universal

Genetic code is universal in nature. One type of code determines the same amino acid in all organisms including viruses, bacteria, plants and animals.

3. Colinearity

The codons in mRNA and the amino acids in polypeptide chains have a linear arrangement.

Colinearity of mRNA and Protein

Genetic Code
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4.Commaless

There is no comma or punctuation between the adjacent codons. That is, each codon is immediately followed by the next codon without any spaces in between.

5. Non-overlapping

Recent discovers show that codons are non-overlapping. Hence each letter is read only once.

Genetic CodeGenetic Code

6. Polarity

The code has a direction or polarity. It is read in only one direction. Usually it is read from the 5/ (5prime) end of mRNA.

 

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