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  Home >> Genetics Dictionary >> Tumor suppressor gene Typology

tRNA
Transfer RNA; and RNA molecule that transfers an amino acid to a growing polypeptide chain during translation.

Truncate

The premature termination of a protein product.

Tuberculosis

An infection of the lungs, accompanied by fever and a loss of appetite, caused by the bacillus Mycobacterium tuberculosis.

Tumor
Abnormal mass of tissue that can be benign or malignant.

Tumor Suppressor Gene

Genes that normally restrain cell growth but, when missing or inactivated by mutation allow the cell to grow uncontrolled.

Tunicate
A group of simple chordates, including sea squirts (class Ascidacea) that live attached to rocks, and the salps (class Thaliacea) that float in the sea. Tunicates are small marine animals, cylindrical, spherical, or irregular in shape, ranging from several millimeters to over 30 cm in size. They have a saclike cellulose tunic covering the body; water is drawn in through a siphon and food particles are filtered out. The free swimming tadpole like larvae show the major characteristics of all chordates. They subsequently undergo metamorphosis, losing their chordate features and becoming adults. One group (class Larvacea) retain their larval characteristics throughout life.

Turner Syndrome
A genetic condition in which an individual is XO (i.e. has only one sex chromosome, an X). Such individuals are phenotypically female, but are sterile because of undeveloped ovaries.

Two Hit Hypothesis (Knudson’s model)

Hypothesis that malignant transformation of cells occurs after at least two cellular mutation events or the “two hit theory”.

Typology

(1) The definition of classificatory groups by phonetic similarity to a “type” specimen. A species, for example, might be defined as all individuals less than x phonetic units from the species’ type. (2) The theory that distinct “types” exist in nature, perhaps because they are part of some plan of nature. (see also idealism.) The type of the species is then the most important form of it, and variants around that type are noise, or “mistakes.” Neo Darwinism opposes typology because in a gene pool no one variant is any more important than any others.

 

 

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