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  Home >> Genetics Dictionary >> Recombination of gene

Recombination
The process by which progeny derive a combination of genes different from that of either parent. In higher organisms, this cur by crossing over.
2. A process of DNA strand exchange between homologous molecules that leads to new combinations of alleles on chromosomes.

3. A event, occurring by the crossing-over of chromosomes during meiosis, in which DNA is exchanged between a pair of chromosomes of a pair.

Thus, two genes that were previously, being on different chromosomes, can become linked ie of recombination, and linked genes may become unlinked.
4. The occurrence of progeny with combinations of genes other those that occurred in the parents, due to independent assortment or crossing over.

5. The formation of new genetic sequences by piecing together segments of previously existing ones. Classical genetics is based an the transmissian of traits, attributable to particular genetic determinants or genes, through sexual generations. The genes are predominantly present in chromosomes, the threadlike structures that fill the cell nucleus and divide as the cells divide. The key component of the chromosomes is deoxyribonucleic acid (DNA); each chromosomes has a single coiled and folded double-stranded DNA molecule running along its length, and the genes of the chromosomes occupy segments of this DNA.

Recombination often follows DNA transfer in bacteria and, in higher organisms, is a regular feature of sexual reproduction. The basic feature of sexual reproduction is the cyclical alternation between the diploid state, with a double set of chromosomes (two of each kind), and the haploid state, with a single set. Animals and most flowering plants are diploid, and their germ cells (eggs and sperm, or eggs and pollen grains) are haploid. In most fungi, the organism is normally haploid, but sexual fertilization creates a transient diploid cell that immediately divides to form a tetrad of four haploid spores.
In all sexually reproducing organisms, the transition from the diploid to the haploid state is brought about by the process of meiosistwo rounds of cell division accompanied by only one division of the chromosomes. The two chromosomes of each kind present into different haploid meiotic products.

Free Reassortment and Linkage
When the diploid cell undergoing meiosis is heterozygous, that is, carries two alternative forms (alleles) of the same gene inherited from different parents, the meiotic segregation of chromosome pairs will ensure that half of the meiotic products (germ cells) will carry one alternative and half the other, When the diploid is doubly heterozygous (A/a B/b), the two pairs of alleles segregate independently of one another at different chromosome pairs. Consequently, four possible productsAB, Ab, aB, and ab will occur with statistically equal frequency. If, in a double heterozygote Aa Cc, the two genes are in the same chromosome and they are not very far apart, they show linkage, with the parental combinations (AC and ac, for example) tending to appear in the meiotic products more frequently than the recombinant types (Ac and aC).

The fact that recombinants types Ac and aC occur at all is due to reciprocal exchanges between chromosomes (crossing over) that take place in the first meiotic division. The reciprocal nature of these events is shown most clearly in fungi such as yeast and the filamentous fungus Neurospora crassa, where to four products of a single meiosis can be recombinant type (Ac) is generally accompanied in the same tetrad by the reciprocal product (aC).

Only two of four tetrad members are generally recombinant Tetrads of constitution AC, Ac, aC ac are far commoner than those containing four recombinant products, the inference being that crossing-over between chromosome pairs occurs after the chromosomes have replicated and that each crossover involves only half of each divided chromosome (chromatid). If more than one crossover occurs within the linkage group, it is a matter of chance which chromatide of each chromosome is involved in each chiasma.

Crossing-over in meiotic tetrads. Only two of the four products usually show crossing-over o linked markers.

Crossing-over in Meiotic Tetrads. Only two of the Four Products Usually show Crossing-over o linked Markers Crossing-over in Meiotic Tetrads. Only two of the Four Products Usually show Crossing-over o linked Markers Crossing-over in Meiotic Tetrads. Only two of the Four Products Usually show Crossing-over o linked Markers

Crossing-over in meiotic tetrads

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