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  Home >> Genetics Dictionary >> Pleiotropy - Polymerase Chain Reaction (PCR)

Pleiotropy
One gene that causes many different physical traits such as multiple disease symptoms. 2. The phenomenon where a single gene is responsible for a number of distinct and seemingly unrelated phenotypic effects.

Ploidy
A term referring to the basic set of chromosomes or multiples of that set.

Point mutation
A mutation that results in the substitution of one nucleotide for another, or the insertion or deletion of one or a few nucleotides.

Pluripotency
The potential of a cell to develop into more than one type of mature cell, depending on environment.

Poisson distribution
A frequency distribution for number of events per unit time, when the number of events is determined randomly and the probability of each event is low.

Polyandry
 A reproductive system in which one female mates with many males. Seahorses and jacanas are examples of polyandrous species, which are less common than monogamous or polygynous species.

Polydactyly
Abnormality where an individual is born with more than the normal number of fingers and/or toes.

Polyadenylation
The addition of a stretch of adenine nucleotides to the 3’ end of a eukaryotic mRNA.

Polymerase chain reaction (PCR)
A method for amplifying a DNA base sequence using a heat stable polymerase and two 20-base primers, one complementary to the (+) strand at one end of the sequence to be amplified and one complementary to the (-) strand at the other end. Because the newly synthesized DNA strands can subsequently serve as additional templates for the same primer sequences, successive rounds of primer annealing, strand elongation, and dissociation produce rapid and highly specific amplification of the desired sequence.

PCR also can be used to detect the existence of the defined sequence in a DNA sample. 2. A method for amplifying DNA segments using a heat-stable DNA polymerase, sequence-specific primers, and cycles of denaturation, annealing, and synthesis.

Polygene

One of a group of gene that together control a quantitative character.

Polygenic disorder
Genetic disorder resulting from the combined action of alleles of more than one gene (e.g., heart disease, diabetes, and some cancers). Although such disorders are inherited, they depend on the simultaneous presence of several alleles; thus of hereditary patterns usually are more complex than those of single-gene disorders.

Polygenic inheritance
The transmission of a phenotypic trait that depends on the additive effects of two or more genes.

Polar body
In oogenesis, a cell produced by either the first or second meiotic division that has almost no cytoplasm due to unequal cytokinesis.

Polygyny
Reproductive strategy in which one male mates with several females. Lions, peacock, and gorillas all have polygynous mating systems. Compare with polyandry and monogamy.

Polylinker
A segment of DNA that has been engineered to include multiple sites for restriction enzyme digestion. Polylinkers are usually  found in engineered vectors such as plasmids.

Polymer
A macromolecule composed of a covalently collection of repeating subunits or monomers linked together during a repetitive series of similar chemical reactions.

 

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