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  Home >>Biotechnology Institutes Directory >>Mass Market Protein : Cure for Stroke

Mass Market Protein : Cure for Stroke
Genetic engineering also allows the bulk production of proteins that were previously available only in tiny amounts. One example is interferon, a molecule produced by the immune system in response to infection. It was once thought that interferon might be a miracle cure for both cancer and the common cold.
Trails proved disappointing, but a recombinant interferon is now on the markets as a treatment for multiple sclerosis, a condition for which there had been no therapeutic drugs. Other examples include the clot-busting drugs, such as tissue plasminogen activator, which save lives when used after heart attacks and, increasingly, stroke (a condition for which there was on treatment).

Also new is the use of antibodies as drugs. These proteins, produced naturally by the immune system and manufactured in mammalian cell lines, can bind to specific molecules in the body and so block their action. They are being developed for use after transplant surgery to neutralise the action of substances that would otherwise trigger rejection, and for treatment of septic shock, cancer and other conditions.

Genetic engineering is also useful in fields other than medicine. Chymosin, the enzyme used to make cheese, can now be produced by yeast. Recombinant chymosin can then be used in the production of vegetarian cheese - in place of rennet extracted from a calls stomach.
Genetic engineering has also been used to create entirely new species of plants and animals. In plants, the new genes are introduced into cell cultures, which are then grown up by the methods of tissue culture described above. Many agriculturally important plant species, including the major food crops such as soya, rice, wheat and corn, have already been transformed.

In theory, plant genetic engineering could improve the world's food supply, disease, weeds and predators account for substantial crop losses, however, and here plant biotechnology can already make an impact.
Transgenic plants bearing a gene for an insecticidal protein from the bacterium Bacillus thuringiensis are being developed to protect crops from insect attack. Plants have also been made resistant to a herbicide called Roundup. This means that a farmer can spray a field of resistant plants knowing that the herbicide will destroy the weeds, but spare the crop.
More transgenic plants will find their way into our food supply before long. The only transgenic products in British shops at the moment are tomato paste and ketchup from transgenic tomatoes. These have been modified so that the gene responsible for making the fruit go soft has been turned off.

The tomatoes stay firm longer and require less energy for processing. It has proved more difficult to create transgenic animals. Here, a fertilized egg is treated with the foreign DNA before it is transferred into the womb of a surrogate mother.

Such animals may be an improvement on the original - fish that grow much faster or animals with more lean than fatty meat, for example.

Researchers have even created pigs with 'humanised' organs to avoid rejection. Such xenografts could make up the shortfall in human donor organs. The animals bear a human protein called daf (decay accelerating factor) on their organs, which enables them to evade rejection by the human immune system.

Several strains of transgenic laboratory animals have also been created. With added human genes, these animals can act as medical models of human disease, such as sickle cell anaemia and Alzheimer's disease, and they may be used to test new drugs and in basic research. (The chapter includes extracts from an article by Susan Aldridge. Courtesy: New Scientist.)

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