A variety of applications for PNAs have been described, which involve the following attributes/uses :
(i) antisense inhibition,
(ii) SI-targeted DNA cleavage and inhibition of cleavage by restriction enzymes,
(iii) detection and analysis of mutations,
(iv) nucleic acid purification,
(v) isolation of transcriptionally active genes,
(vi) enhanced PCR amplification,
(vii) blocking of the binding of transcription factors,
(viii) inhibition and monitoring of telomere length,
(ix) use in biosensors,
(x) inhibition of translation by PNA clamps,
(xi) in situ hybridization and
(xii) alternative to Southern blotting.
|
