DNA microarrays and proteomics
Like genomics, the term 'proteomics' relates to the study of proteins and the protein-protein interactions. DNA chips can also be used for this purpose. Protein linkage map can also be created using genomic sequence information. Protein-protein interactions are generally studied by yeast two hybrid system. In this system genomic clones of two fusion proteins are used for the activation of transcription of a reporter gene in yeast.

The first fusion protein contains a DNA binding domain fused to a protein of interest and the second fusion protein carries an acidic transcription activation domain fused to the protein, whose interaction with the first protein of interest is being examined Scientific interaction between two chimeric (fused) proteins leads to transcriptional activation, thus confirming protein-protein interaction. The identity of the two proteins of interest is confirmed by sequence analysis of each clone thus identified. Therefore, major sequencing work is involved in the above two hybrid system.