Swiss Prot Prosite and Expasy, PC/Gene, Amos Bairoch, Nucleic Acid, Protein Sequence, Tertiary Structure

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Home >> Biotechnology and Genomics >> Bioinformatics and Data Mining - In Silico Biology >> SWISS-PORT, PROSITE and ExPAsy

Your Ad Here	SWISS-PROT, PROSITE and ExPASy In 1986, a protein database called SWISS-PROT was made available by Amos Bairoch, independently of PC/Gene, the latter containing both nucleic acid and protein sequences. SWISS-PROT contained only 3,900 sequences in July 1986. It was also known at that time that in the amino acid sequences of proteins, there are many short sequences, which may represent binding sites or active sites., A collection of these sequences and the patterns they make were available and could be searched in any given sequence. PROSITE is another program which can scan a given sequence for one or more of these short sequences and patterns, which were as many as -1500 in number in the year 2000. PROSITE also contains patterns which some of these short sequences will make, so that it is a hybrid, half program and half database
Together, the different versions of SWISS-PROT and PROSITE, that were made available by Amos Bairoch, led to the discovery of many protein domains. Other related databases that became available in 1990s include PRINTS, BLOCKS, PRODOM and Pfam, which were complementary algorithms to detect and classify protein domains and families. All these databases/programs were later combined into a project called INTERPRO, which could identify protein families/domains
In the year 1993-94, Amos Bairoch also developed a system, called ExPAsy (Expert Protein Analysis System), which if presented with a protein sequence, gives information on the following aspects of this protein: (i) some hint about its function; (ii) its similarities to other position and (iii) a tertiary structure model, if possible. It also proposes experiments that will prove or disprove the conclusions made. During 1993-2000, ExPAsy was constantly evolved, accessed 60 million times by more than 820,000 computer hosts from 151 countries	Your Ad Here

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