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Home >> Dictionary of Bioinformatics, Biochemistry, Biotechnology >> Nanobiotechnology

N2
Free nitrogen gas.It is used as a cryopreservant in liquid form.

N-acetylneuraminic acid (NANA)
An example of a Sialic acid. A molecule linked to a glycoprotein that forms the red blood cell membrane receptor for influenza virus. The receptor is inactivated by neuraminidase, which cleaves the NANA residue.

N-banding
A technique for specifically staining Nucleolar organiser regions (eg. silver staining).

N- cadherins
The most well characterised CAMs found in the neurons. Ca2+ ions are positioned between each pair of cadherin repeats to form a stiff, rodlike structure. When the cadherins are removed, the extracellular region of the protein becomes floppy and undergoes proteolytic degradation.

N-CAM
See neural cell adhesion molecule.

N-end rule
The N-terminal amino acids in a protein that play a role in the regulation of protein turnover by targeting the protein for ubiquitination.

N-linked oligosaccharide
A chain of sugars attached to a protein via the amino group of the side chain of an asparagine residue.

N-terminus
Amino terminus of a protein defined by the amino group of an amino acid.

Na+K+ pump (Na+K+ATPase)
A transmembrane carrier protein located in the plasma membrane of animal cells that pumps Na+ out of the cell in exchange for K+ which enters the cell coupled with ATP hydrolysis.

NAD+, NADP+
(nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate). Coenzymes containing nicotinamide that function as carriers of hydrogen atoms and electrons in oxidation-reduction reactions. NADH and NADPH are the reduced forms of the cofactor. NADPH  is used for biosynthetic reductions.

NAD+

NAD+


Naked DNA
Pure, isolated DNA free DNA-binding proteins.

Nalidixic acid
A synthetic antibiotic that mimics the action of the natural antibiotic novobiocin.

NANA
See N-acetylneuraminic acid.

Nono (n)
SI prefix, 109.

Nanobiotechnology
An emerging area of high scientific and technological opportunity. It involves the processing, fabrication, and packaging of organic or biomaterial devices or assemblies in which the dimension of at least one functional component lies between atomic lengths and the wavelength of visible light. There are two basic approaches to creating these structures-the bottom up and top down approaches. The bottom up approach exploits the structures and processes of biomolecules to created novel functional materials, biosensors, and bioelectronics for biological and medical applications.

This field encompasses many disciplines including organic chemistry, molecular biology, materials science, and bioanalytics. It explores and develops interphase systems, protein-based nanostructures, and DNA-based nanostructures. The top down approach, involves application of the tools and processes of nano/microfabrication to build devices for studying for studying Biosystems. Micro/nanofabrication requires optical and electron beam lithography and processing larger substrate materials into structures with very fine surface features.

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