Microarray
A2D array, generally on a glass, filter, or silicon wafer, on which genes, gene fragments or oligonucleotides are deposited or synthesised in a predetermined spatial order allowing them to be made available as probes in a high-throughtput, parallel manner. It is used for comparative analysis and differential studies of genomes and transcriptomes. Also known as biochip or DNA chip.
MicroArray and Gene Expression Markup Language (MAGE-ML)
A language designed to describe and communicate information about microarray based experiments. MAGE-ML is based on XML and can describe microarray designs, microarry manufacturing information, microarray experiment setup and execution information, gene expression data and data analysis results. MAGE-ML has been automatically derived from Microarray Gene Expression Object Model (MAGE-OM), which is developed and described using the Unified Modelling Language (UML)-a standard language for describing object models.
Microarray technology
A method of analysing the interaction of large number of genes with each other and the simultaneous regulation of batteries of genes. A robot is used to apply tiny droplets of functional DNA onto glass slides. Fluorescently labelled DNA probes are allowed to hybridise to the complementary strands on the slides. A scanning microscope measures the brightness of each fluorescent dot on the slide. The intensity of fluorescence indicates the amount of a specific DNA fragment and thereby information whether it is overexpressed or downregulated.
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