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Home >> Dictionary of Bioinformatics, Biochemistry, Biotechnology >> Lysosome

Lymphocytes  A type of leukocytes that bear antigen-specific receptors and are involved in the immune response. Lymphocytes are small cells without cytoplasm, found in blood, in all tissues, and in lymphoid organs, such as lymph nodes, spleen, and Peyer’s patches. While B lymphocytes synthesise and secrete antibodies, T lymphacytes have a regulatory role in cell mediated immunity.

Lymphoid organs Organs that are involved in the production or function of lymphocytes. These include the thymus, spleen, lymph nodes and tonsils.

Lymphoid progenitor A precursor of both T and B lymphocytes.

Lymphokine A generic name for proteins (eg. interleukins and interferons) that are released  by lymphocytes to act on other cells involved in the immune response.

Lymphokine-activated killer cell (LAL) A natural killer cell activated by interleukin-2 to become cytotoxic.

Llymphoma Cancer originating in the lymph nodes, spleen and other lymphoreticular sites.

Lyon effect The silencing of expression of one of the two X chromosomes in a female animal. This occurs at random and is maintained in all progeny cells.

Lyophilisation The removal of water from a frozen biological specimen by placing in vacuum. Also called freeze-drying.

Lyophilize Rapid freezing followed by dehydration under high vacuum. The process is termed lyophilisation. See freeze-drying.

Lysate A mixture of cell debris and soluble cytoplasmic substances formed from lysis of a cell culture or tissue.

Lysis 1. Destruction of bacteria at the end of a phage infective cycle by breakage of cells. 2. Breaking open of cells by damage to the cell membrane by a physical, chemical or biological agent.

Lysogen A bacterium that contains a repressed phage as part of its genome.

Lysogenic bacteria Bacteria that harbour temperate (non-virulent, lysogenic) bacteriophages.

Lysogenic immunity The ability of a phage to prevent another phage of the same type from becoming established in the bacterium.

Lysogenic merozyte See addition transduction.

Lysogenic repressor  A protein responsible for preventing a phage from reentering the lytic cycle.

Lysogeny A state in which a phage genome (Prophage) integrated into the host chromosome or extra chromosomal element remains dormant without initiation lysis.

Lysophospholipids Phosphoacylglycerols that contain only one acyl radical (eg. lysolecithin).

Lysosimal chilesteryl esterase (acid lipase) An enzyme that cleaves the cholesteryl esters of LDL, liberating cholesterol.

Lysosome A membrane-bound subcellular organelle present in the cytoplasm of animals cells that contains hydrolytic enzymes for the breakdown of proteins. It is responsible for the digestion of material in food vacuoles, dissolution of foreign particles entering the cell and, break down of cell structure after cell death.

Lysozyme An enzyme that catalyses the breakdown of polysaccharide chains in the cell walls of bacteria. The enzyme is present in saliva and tears.

Lytic cycle Multiplication of a bacteriophage in a host cell that eventually leads to the lysis of the cell and infection of other bacteria.

Lytic virus A virus that causes lysis of the cells that it infects.

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