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Home >> Dictionary of Bioinformatics, Biochemistry, Biotechnology >> Cytokine Receptor - Cytosolic Processing Pathway


Cytokeratins

Proteins in the epithelial cells that make up the intermediate filaments. Expression of keratins is used in the diagnosis of epithelial tumours.

Cytokine antagonist
A molecule that interfers with cytokine function.

Cytokine pleiotropism
A cytokine that has more than one functions.

Cytokine receptor
A member of a class of cell-surface signalling receptors, such as the receptors for erythropoietin, growth hormone, interferon etc.

The receptor dimerises on binding to the ligand and activates cytosolic JAK kinases associated with the intercellular domain of the receptor, initiating signal transduction.

Cytokine redundancy
Refers to cytokines that have the same function.

Cytokines
Small proteins that bind to cell surface receptors on some cells influencing their proliferations or differentiation. For example, interleukins and interferons.

Cytoplasm
The portion of the contents of a cell within the plasma membrane but outside the nucleus that includes the various organelles.

Cytoplasmic genes
DNA-containing bodies in the cell that are external to the nucleus.

Cytoplasmic inheritance
Hereditary transmission dependent on the cytoplasm or organelles in the cytoplasm rather than the nuclear genes, extrachromosomal inheritance. For example, mitochondrial and chloroplast characteristics are inherited by a mechanism independent of nuclear genes.

Cytoplasmic male sterility
Genetic defect that arises as a result of defective functions of mitochondria in the pollen due to which fertilisation does not occur. This phenomenon is exploited in certain plant breeding strategies, such as F1-hybrid maize cultivars.

Cytoplasmic organelles
Discrete subcellular structures found in the cytoplasm of cells. These have specific functions in the cell.

Cytoplasmic protein synthesis
Translation of mRNAs representing nuclear genes that takes place on ribosomes attached to the cytoskeleton.

Cytosine
A nitrogenous pyrimidine base found in DNA and RNA.

Cytosine

Cytosine

Cytosine arabinoside (ara-C)
An analog of deoxycytidine that is incorporated into DNA. It kills cells in S phase and also blocks cells in the G1-S boundary, thereby preventing these cells from entering the S phase. It is used as a cancer chemotherapeutic agent.

Cytoskeleton
A network of filaments comprised of actin, microtubules, etc., that provides structure and organisation to the cytoplasm.

Cytosol
The aqueous phase of the cytoplasm comprised of dissolved soluted but excluding the organelles

Cytosolic processing pathway
A pathway for processing endogenous cytosolic antigens for presentation on class I MHC.

Cytotoxic (cytolytic) T cell
A cell that kills target cells harbouring appropriate antigen within the groove of an MHC class I molecule that is identical to that of the T cell. It kills virus-infected cells and tumour cells.

Cytotype
A characteristic conferred by an agent in the cytoplasm rather than in the nucleus. This is maternally inherited. Refers to characteristics specified by cytoplasmic genes as well as those specified by the products of nuclear genes, which are synthesized in and function in the cytoplasm.

Cytoplasmic segregation
The generation of homoplasmic cells from heteroplasmic cells during mitotic division. This reflects random partition of organelle population between daughter cells, a stochastic process that leads to bias further exaggerated through rounds of division. The daughter cells are homoplasmic after several generations.

Cytoplasmic streaming
The back-and-forth movement of cytoplasm in certain algae and the circular flow of cytoplasm around a central vacuole in a plant cell. Also termed cyclosis.

Cytoplasmic trait
A genetic characteristic in which the genes are found outside the nucleus such as the mitochondria or chloroplast. This results in offspring that inherit genetic material from only one parent, usually maternal.

Cytokinesis
Cytoplasmic division and changes other than nuclear division that are a part of mitosis or meiosis. See cell division.

Cytokinin
Plant growth regulators (hormones) that stimulate cell division and cell differentiation. These compounds are derivatives of adenine. In tissue culture, these hormones are associated with enhanced callus and shoot development.

Cytological hybridization
See in situ hybridization.

Cytology
The study of the structure and function of cells.

Cytolysis
Cell disintegration.

Cytomegalovirus (CMV)
A nonpathogenic human virus that can become pathogenic in immunocompromised hosts. Following infection, the virus persists in the host. A carrier is however protected in the virus by both T-cell and humoral immunity. The CMV promoter has been incorporated into many plasmid vectors so that mammalian genes cloned can be expressed.

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