Gene Therapy Introduction, Human Disease, Catenin, Human Medical Gene, Genetic disease, Medical Genetic Research

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Gene Therapy Gene Therapy Introduction Current Therapies for 10 Single Gene Human Disorders Somatic Versus Germ-Line Gene Therapy Gene Therapy in PhaseII Clinical Studies First Approved Trial Foetal Gene Therapy Results of Animal Gene Therapy Gene Therapy Process Gene Delivery Gene Transfer Techniques Physical Transfection Methodsl Liposome Mediaed DNA Transfer Receptor Mediated Endocytosis

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Gene Therapy
Genes are the blueprint of our bodies, governing factors such as growth, development and functioning. Excitement has come from the finding that genes that guide cell differentiation and pattern formation are linked to human disease. A genetic mutation means that a gene contains a fault or “spelling mistake” that disrupts the gene message. A fault in a gene can occur spontaneously or can be inherited. Genetic faults in a gene can a wide range of disorders and be involved in susceptibility to some cancers. For examples, mutation in β-catenin contributes to human colon and other cancers (Morin et al., 1997)

The primary goal of human medical genetic research is to develop treatments for each of the many different genetic diseases. A few gene products, the characteristics of the disease caused by mutations in the genes that encode these products, and the current treatments

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Naked DNA Herpes Simplex Virus Vectors Lentiviruses Non Viral Vector Systems for Gene Therapy Liposomes Direct Injection / Particle Bombardment Receptor Mediated Endocytosis Gene Therapy of Inherited Disorders First Gene Therapy Trail in 1990 Gene Therapy Trails for Few Inherited Disorders Familial Hypercholesterolaemia Cystic Fibrosis Duchenne Muscular Dystrophy Recent and Future Development in Gene Therapy Gene Therapy Arguments Retroviruses Adenoviruses Herpesvirus Target Tissues Diseases Amenable to Gene Therapy Adenosine Deaminase ADA Deficiency Cancer Peripheral Vascular Disease Coronary Artery Disease Haemophilia Cystic Fibrosis The Immune System Risks of Gene Therapy Recent Developmentsin Gene Therapy Arguments in Favour of Gene Therapy Arguments Against Gene Therapy When Should We Use Gene Therapy Future Prospects